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Results

We observed a significant decline in cell proliferation after treatment with γ-secretase inhibitors, and in combination with RT and temozolomide. In addition, we observed a comprehensive targeting of Notch pathway, both at canonical and non-canonical levels. All these phenotypic effects were augmented with a synergy of these inhibitors with both RT and temozolomide. Lastly, we observed context-specific effects of targeting Notch receptors on cell proliferation, invasion, EMT, and their cross-talk with other radioresistance pathways.

Conclusion

Targeting notch pathway modulates the vital cellular processes that are implicated in the tumorigenesis of the gliomas. All these endeavors may lead to better treatment outcomes for the patients. Further studies to authenticate the druggability of notch effectors and their interacting partners should be investigated to determine if this combinatorial targeting could be used …