作者
Roberto Queiroga Lautner, Daniel C Villela, Rodrigo A Fraga-Silva, Neiva Silva, Thiago Verano-Braga, Fabiana Costa-Fraga, Joachim Jankowski, Vera Jankowski, Frederico Sousa, Andreia Alzamora, Everton Soares, Claudiane Barbosa, Frank Kjeldsen, Aline Oliveira, Janaina Braga, Silvia Savergnini, Gisele Maia, Antonio Bastos Peluso, Danielle Passos-Silva, Anderson Ferreira, Fabiana Alves, Almir Martins, Mohan Raizada, Renata Paula, Daisy Motta-Santos, Friederike Kemplin, Adriano Pimenta, Natalia Alenina, Ruben Sinisterra, Michael Bader, Maria Jose Campagnole-Santos, Robson AS Santos
发表日期
2013/4/12
期刊
Circulation research
卷号
112
期号
8
页码范围
1104-1111
出版商
Lippincott Williams & Wilkins
简介
Rationale:
The renin–angiotensin system (RAS) is a key regulator of the cardiovascular system, electrolyte, and water balance. Here, we report identification and characterization of alamandine, a new heptapeptide generated by catalytic action of angiotensin-converting enzyme-2 angiotensin A or directly from angiotensin-(1–7).
Objective:
To characterize a novel component of the RAS, alamandine.
Methods and Results:
Using mass spectrometry we observed that alamandine circulates in human blood and can be formed from angiotensin-(1–7) in the heart. Alamandine produces several physiological actions that resemble those produced by angiotensin-(1–7), including vasodilation, antifibrosis, antihypertensive, and central effects. Interestingly, our data reveal that its actions are independent of the known vasodilator receptors of the RAS, Mas, and angiotensin II type 2 receptor. Rather, we demonstrate that …
学术搜索中的文章
RQ Lautner, DC Villela, RA Fraga-Silva, N Silva… - Circulation research, 2013
