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RNA modifications play a key role in the regulation of gene expression. Among them, N6-methyladenosine (m6A) is the most prevalent mRNA modification. m6A methylation modulates the gene expression by influencing numerous aspects of mRNA metabolism, including pre-mRNA processing, nuclear export, and translation. Many studies have demonstrated the importance of m6A-mediated post-transcriptional gene regulation in numerous physiological and pathophysiological processes, especially in tumorigenesis. This modification is dynamically modulated by proteins such as methyltransferases (writers), demethylases (erasers) and, recruitment of m6A-binding proteins (readers). In this study we investigated the different m6A methylation patterns between HeLa, SiHa and C33A cervical cancer (CC) cell lines and normal HCK1T cervical keratinocyte cells.

Gene expression …