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LIMA1 or EPLIN is a cytoskeleton-associated protein involved in cytoskeleton regulation and dynamics, by inhibiting actin filament depolymerization and cross-linking filaments. The role of LIMA1 has been investigated in several malignant diseases including prostate, esophageal, breast and ovarian cancer. Its expression is often lost or aberrant in tumor cells leading to aggressive phenotypes. The aim of this study was to systematically assess the expression of LIMA1 in cervical cancer.

Immunohistochemical analysis using anti-EPLIN antibody was performed in 22 cases of cervical intraepithelial neoplasia, 14 cases of adenocarcinoma including one case with mucinous and one case with endometrioid adenocarcinoma, 5 cases of adenosquamous carcinoma, 25 cases of squamous cell carcinoma and 11 normal samples. The correlation of LIMA1 aberrant expression and …