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Cervical cancer (CC) remains the fourth most common and lethal cancer type in women; therefore, a comprehensive understanding of the underlying mechanisms and development of novel diagnostic, prognostic and therapeutic approaches are critical steps for improving CC management. We have previously performed a detailed comparative proteomic analysis between HeLa, SiHa and CD33A CC cell lines and the normal cervical keratinocytes HCK1T cells (Pappa et al, Oncol Rep. 42:1441, 2019) aiming to elucidate novel and potential therapeutic targets. Among hundreds of deregulated proteins between cancer and normal cell lines, LIMA1 or EPLIN, a protein decreased or lost in neoplasia, was statistically downregulated in all CC cell lines. Since LIMA1 role in CC is not fully elucidated yet, we aimed to downregulate its expression in HCK1T cells and assess the putative induction of …