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To demonstrate the feasibility of microwave‐induced thermoacoustic tomography (TAT) of adult human brain.

We analyzed the electric field distribution radiated from an antenna to acquire homogeneous illumination. We first imaged the anatomical structures in a rat's trunk to validate the thermoacoustic contrast in vivo. We then imaged an agar cylinder through an adult human skull ex vivo to demonstrate transcranial penetration of both microwave and ultrasound. We also analyzed the specific absorption rate to show the conformance to the safety standard for human electromagnetic exposure.

We successfully acquired cross‐sectional images of the rat's trunk in vivo. Major blood vessels and organs are clearly visible. The transcranial image shows that TAT can image through the adult human skull and reveal an agar enclosed by the skull.

Microwave‐induced TAT of a rat's …