作者
Somashekar G Krishna, Phil A Hart, John M DeWitt, Christopher J DiMaio, Pradermchai Kongkam, Bertrand Napoleon, Mohamed O Othman, Damien Meng Yew Tan, Sebastian G Strobel, Peter P Stanich, Anand Patel, Anjuli K Luthra, Megan Q Chan, Alecia M Blaszczak, Dana Lee, Samer El-Dika, Sean T McCarthy, Jon P Walker, Christina A Arnold, Kyle Porter, Darwin L Conwell
发表日期
2020/3/1
期刊
Gastrointestinal Endoscopy
卷号
91
期号
3
页码范围
551-563. e5
出版商
Mosby
简介
Background and Aims
Previous studies have validated EUS-guided needle-based confocal laser endomicroscopy (nCLE) diagnosis of intraductal papillary mucinous neoplasms (IPMNs). We sought to derive EUS-guided nCLE criteria for differentiating IPMNs with high-grade dysplasia/adenocarcinoma (HGD-Ca) from those with low/intermediate-grade dysplasia (LGD).
Methods
We performed a post hoc analysis of consecutive IPMNs with a definitive diagnosis from a prospective study evaluating EUS-guided nCLE in the diagnosis of pancreatic cysts. Three internal endosonographers reviewed all nCLE videos for the patients and identified potential discriminatory EUS-guided nCLE variables to differentiate HGD-Ca from LGD IPMNs (phase 1). Next, an interobserver agreement (IOA) analysis of variables from phase 1 was performed among 6 blinded external nCLE experts (phase 2). Last, 7 blinded nCLE-naïve …
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SG Krishna, PA Hart, JM DeWitt, CJ DiMaio… - Gastrointestinal Endoscopy, 2020