作者
Chuanshan Zhang, Renyong Lin, Zhide Li, Shuting Yang, Xiaojuan Bi, Hui Wang, Abudusalamu Aini, Ning Zhang, Abuduaini Abulizi, Cheng Sun, Liang Li, Zhibin Zhao, Rongde Qin, Xiaohong Li, Liang Li, Tuerganaili Aji, Yingmei Shao, Dominique A Vuitton, Zhigang Tian, Hao Wen
发表日期
2020/4
期刊
Hepatology
卷号
71
期号
4
页码范围
1297-1315
简介
Background and Aims
The cestode Echinococcus multilocularis infection, a serious health problem worldwide, causes alveolar echinococcosis (AE), a tumor‐like disease predominantly located in the liver and able to spread to any organs. Until now, there have been few studies that explore how T‐cell exhaustion contributes to the parasite’s escape from immune attack and how it might be reversed.
Approach and Results
In this study, we found that liver T‐cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine‐based inhibitory motif domain (TIGIT) expression was significantly enhanced and positively correlated with lesion activity in AE patients. High TIGIT expression in both liver‐infiltrating and blood T cells was associated with their functional exhaustion, and its ligand CD155 was highly expressed by hepatocytes surrounding the infiltrating lymphocytes. In co‐culture experiments using human …
学术搜索中的文章
C Zhang, R Lin, Z Li, S Yang, X Bi, H Wang, A Aini… - Hepatology, 2020