作者
Harriet C Thoeny, Frederik De Keyzer, Feng Chen, Yicheng Ni, Willy Landuyt, Eric K Verbeken, Hilde Bosmans, Guy Marchal, Robert Hermans
发表日期
2005/3
期刊
Radiology
卷号
234
期号
3
页码范围
756-764
出版商
Radiological Society of North America
简介
PURPOSE: To evaluate diffusion-weighted magnetic resonance (MR) imaging for monitoring tumor response in rats after administration of combretastatin A4 phosphate.
MATERIALS AND METHODS: Study protocol was approved by local ethical committee for animal care and use. Rhabdomyosarcomas implanted subcutaneously in both flanks of 17 rats were evaluated with 1.5-T MR unit by using four-channel wrist coil. Transverse T2-weighted fast spin-echo sequences, T1-weighted spin-echo sequences before and after gadodiamide administration, and transverse echo-planar diffusion-weighted MR examinations were performed before, 1 and 6 hours, and 2 and 9 days after intraperitoneal injection of vascular targeting agent (combretastatin A4 phosphate, 25 mg/kg). Apparent diffusion coefficient (ADC) was automatically calculated from diffusion-weighted MR imaging findings. These findings were …
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HC Thoeny, F De Keyzer, F Chen, Y Ni, W Landuyt… - Radiology, 2005