作者
Mary Clare McKenna, Rangariroyashe H Chipika, Stacey Li Hi Shing, Foteini Christidi, Jasmin Lope, Mark A Doherty, Jennifer C Hengeveld, Alice Vajda, Russell L McLaughlin, Orla Hardiman, Siobhan Hutchinson, Peter Bede
发表日期
2021/12
期刊
Journal of neurology
卷号
268
期号
12
页码范围
4687-4697
出版商
Springer Berlin Heidelberg
简介
The contribution of cerebellar pathology to cognitive and behavioural manifestations is increasingly recognised, but the cerebellar profiles of FTD phenotypes are relatively poorly characterised. A prospective, single-centre imaging study has been undertaken with a high-resolution structural and diffusion tensor protocol to systematically evaluate cerebellar grey and white matter alterations in behavioural-variant FTD(bvFTD), non-fluent variant primary progressive aphasia(nfvPPA), semantic-variant primary progressive aphasia(svPPA), C9orf72-positive ALS-FTD(C9 + ALSFTD) and C9orf72-negative ALS-FTD(C9-ALSFTD). Cerebellar cortical thickness and complementary morphometric analyses were carried out to appraise atrophy patterns controlling for demographic variables. White matter integrity was assessed in a study-specific white matter skeleton, evaluating three diffusivity metrics: fractional anisotropy …
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