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A recent study found that depression is inversely associated with insulin resistance, but positively associated with diabetes. 1 Association between insulin resistance and depression is a poorly studied area and the few earlier findings do not necessarily support this finding, 1 indicating that patients with serious depression have insulin resistance assessed by insulin tolerance, intravenous, or oral glucose tolerance tests. 2 Recently, depression was found to be associated with greater insulin resistance in women with polycystic ovary syndrome. 3 Also, more than the normal rates of depression had already been noted in patients with clinically manifest diabetes. 2 Since insulin resistance is positively associated with the development of diabetes, 1 we hypothesised—given that disturbed glucoregulatory functions behind the development of diabetes might be associated with pathophysiological changes in depression2 …