作者
R Monina Klevens, Jeremy T Miller, Kashif Iqbal, Ann Thomas, Elena M Rizzo, Heather Hanson, Kristin Sweet, Quyen Phan, Alicia Cronquist, Yury Khudyakov, Guo-liang Xia, Philip Spradling
发表日期
2010/11/8
期刊
Archives of internal medicine
卷号
170
期号
20
页码范围
1811-1818
出版商
American Medical Association
简介
Background
The incidence of hepatitis A virus (HAV) disease is the lowest ever in the United States. We describe recent incidence and characteristics of cases of HAV disease from 6 US sites conducting hepatitis surveillance in the Emerging Infections Program.
Methods
Health departments conducted enhanced, population-based surveillance for HAV from 2005 through 2007. Demographic and risk factor data were collected on suspected cases (persons with a positive IgM anti-HAV result) using a standard form. Remnant serum specimens from a convenience sample of cases were tested by polymerase chain reaction, followed by sequencing the 315-nucleotide segment of the VP1-P2B junction.
Results
There were 1156 HAV cases reported during 2005 through 2007. The combined population under surveillance was 29.8 million in 2007. The overall annual incidence rate was 1.3 per 100 000 population (range by …
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RM Klevens, JT Miller, K Iqbal, A Thomas, EM Rizzo… - Archives of internal medicine, 2010