作者
Evangelos K Oikonomou, Mohamed Marwan, Milind Y Desai, Jennifer Mancio, Alaa Alashi, Erika Hutt Centeno, Sheena Thomas, Laura Herdman, Christos P Kotanidis, Katharine E Thomas, Brian P Griffin, Scott D Flamm, Alexios S Antonopoulos, Cheerag Shirodaria, Nikant Sabharwal, John Deanfield, Stefan Neubauer, Jemma C Hopewell, Keith M Channon, Stephan Achenbach, Charalambos Antoniades
发表日期
2018/9/15
期刊
The Lancet
卷号
392
期号
10151
页码范围
929-939
出版商
Elsevier
简介
Background
Coronary artery inflammation inhibits adipogenesis in adjacent perivascular fat. A novel imaging biomarker—the perivascular fat attenuation index (FAI)—captures coronary inflammation by mapping spatial changes of perivascular fat attenuation on coronary computed tomography angiography (CTA). However, the ability of the perivascular FAI to predict clinical outcomes is unknown.
Methods
In the Cardiovascular RISk Prediction using Computed Tomography (CRISP-CT) study, we did a post-hoc analysis of outcome data gathered prospectively from two independent cohorts of consecutive patients undergoing coronary CTA in Erlangen, Germany (derivation cohort) and Cleveland, OH, USA (validation cohort). Perivascular fat attenuation mapping was done around the three major coronary arteries—the proximal right coronary artery, the left anterior descending artery, and the left circumflex artery. We …
学术搜索中的文章
EK Oikonomou, M Marwan, MY Desai, J Mancio… - The Lancet, 2018