作者
Ning Li, Thomas A Csepe, Brian J Hansen, Lidiya V Sul, Anuradha Kalyanasundaram, Stanislav O Zakharkin, Jichao Zhao, Avirup Guha, David R Van Wagoner, Ahmet Kilic, Peter J Mohler, Paul ML Janssen, Brandon J Biesiadecki, John D Hummel, Raul Weiss, Vadim V Fedorov
发表日期
2016/8/9
期刊
Circulation
卷号
134
期号
6
页码范围
486-498
出版商
Lippincott Williams & Wilkins
简介
Background
Adenosine provokes atrial fibrillation (AF) with a higher activation frequency in right atria (RA) versus left atria (LA) in patients, but the underlying molecular and functional substrates are unclear. We tested the hypothesis that adenosine-induced AF is driven by localized reentry in RA areas with highest expression of adenosine A1 receptor and its downstream GIRK (G protein-coupled inwardly rectifying potassium channels) channels (IK,Ado).
Methods
We applied biatrial optical mapping and immunoblot mapping of various atrial regions to reveal the mechanism of adenosine-induced AF in explanted failing and nonfailing human hearts (n=37).
Results
Optical mapping of coronary-perfused atria (n=24) revealed that adenosine perfusion (10–100 µmol/L) produced more significant shortening of action potential durations in RA (from 290±45 to 239±41 ms, 17.3±10.4%; P<0.01) than LA (from 307±24 to 286 …
学术搜索中的文章
N Li, TA Csepe, BJ Hansen, LV Sul… - Circulation, 2016
