作者
Giuseppe Fanetti, Daniela Alterio, Giulia Marvaso, Sara Gandini, Damaris Patricia Rojas, Carlo Gobitti, Emilio Minatel, Alberto Revelant, Angela Caroli, Claudia Maria Francia, Ombretta Alessandro, Matteo Pepa, Simone Giovanni Gugliandolo, Anna Starzyńska, Jerry Polesel, Emanuela Vaccher, Maria Cossu Rocca, Marta Tagliabue, Mohssen Ansarin, Valentina Lupato, Vittorio Giacomarra, Antonino De Paoli, Roberto Orecchia, Giovanni Franchin, Barbara Alicja Jereczek‐Fossa
发表日期
2020/10
期刊
Oral Diseases
卷号
26
期号
7
页码范围
1384-1392
简介
Aim
To evaluate the role of baseline neutrophil‐to‐lymphocyte ratio (NLR) as prognostic marker in squamous cell carcinoma of the oropharynx (OPC) treated with definitive chemoradiotherapy (CRT) in the era of HPV status.
Patients and methods
A retrospective analysis of 125 patients (pts) affected with locally advanced OPC was performed. Inclusion criteria were age >18 years, stage III or IV (TNM 7th ed.) and definitive CRT. Haematological marker for their independent role as prognostic biomarkers for progression‐free survival (PFS) and overall survival (OS). Logistic models were used to assess the association with downstage in TNM 8th ed.
Results
Seventy‐seven (61.6%) pts had HPV/p16 + related OPC. Therapeutic choice consisted in sequential and concurrent CRT. Median follow‐up was 50 months. A value of NLR ≥3 was associated with poorer OS. Two‐year OS was 91% and 81% in pts with NLR <3 …
学术搜索中的文章
Prognostic significance of neutrophil‐to‐lymphocyte ratio in HPV status era for oropharyngeal cancer
G Fanetti, D Alterio, G Marvaso, S Gandini, DP Rojas… - Oral Diseases, 2020