作者
Amélie Trinquand, Aline Tanguy-Schmidt, Raouf Ben Abdelali, Jérôme Lambert, Kheira Beldjord, Etienne Lengliné, Noémie De Gunzburg, Dominique Payet-Bornet, Ludovic Lhermitte, Hossein Mossafa, Véronique Lhéritier, Jonathan Bond, Françoise Huguet, Agnès Buzyn, Thibaud Leguay, Jean-Yves Cahn, Xavier Thomas, Yves Chalandon, André Delannoy, Caroline Bonmati, Sebastien Maury, Bertrand Nadel, Elizabeth Macintyre, Norbert Ifrah, Hervé Dombret, Vahid Asnafi
发表日期
2013/12/1
期刊
Journal of clinical oncology
卷号
31
期号
34
页码范围
4333-4342
出版商
American Society of Clinical Oncology
简介
Purpose
The Group for Research in Adult Acute Lymphoblastic Leukemia (GRAALL) recently reported a significantly better outcome in T-cell acute lymphoblastic leukemia (T-ALL) harboring NOTCH1 and/or FBXW7 (N/F) mutations compared with unmutated T-ALL. Despite this, one third of patients with N/F-mutated T-ALL experienced relapse.
Patients and Methods
In a series of 212 adult T-ALLs included in the multicenter randomized GRAALL-2003 and -2005 trials, we searched for additional N/K-RAS mutations and PTEN defects (mutations and gene deletion).
Results
N/F mutations were identified in 143 (67%) of 212 patients, and lack of N/F mutation was confirmed to be associated with a poor prognosis. K-RAS, N-RAS, and PTEN mutations/deletions were identified in three (1.6%) of 191, 17 (8.9%) of 191, and 21 (12%) of 175 patients, respectively. The favorable prognostic significance of N/F mutations was …
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A Trinquand, A Tanguy-Schmidt, R Ben Abdelali… - Journal of clinical oncology, 2013