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Since the report of the first cases in December 2019, infection with the severe acute respiratory coronavirus 2 (SARS-CoV-2) commonly referred as COVID-19 has become a worldwide pandemic. 1 In patients with COVID-19 infection, respiratory deterioration has been associated with not only increased viral loads in the lung but also with an inadequate and exaggerated immune response. 2 Preclinical data have demonstrated a role for complement activation in CoV-mediated disease. Gralinski et al., found activation of the complement system in a mouse model of CoV. 3 In some patients with COVID-19, significant deposits of terminal complement components C5b-9 (membrane attack complex), C4d, and mannose binding lectin (MBL)-associated serine protease 2 (MASP-2) have been found in the microvasculature of different organs, consistent with sustained, systemic activation of the lectin-complement pathway …