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One of the subjects under debate in sentinel node mapping is the eligibility of patients with the history of previous surgical biopsy of the primary lesion for sentinel node biopsy. In the current systematic review, we evaluated the false negative and detection rates of sentinel node biopsy in breast cancer patients with and without previous surgical manipulation of the primary breast lesions.

Pubmed, SCOPUS, and Google scholar were searched for any relevant study with head to head comparison of patients with and without history of previous surgical manipulation of the primary breast lesions. The outcomes of interest were detection and false negative rates in each group, and odds ratio as well as risk difference of having sentinel node detection failure or getting false negative results in the surgical biopsy compared to the non-surgical biopsy group.

18 studies for false negative …