作者
Charalambos Antoniades, Cheerag Shirodaria, Paul Leeson, Alexios Antonopoulos, Nicholas Warrick, Tim Van-Assche, Colin Cunnington, Dimitris Tousoulis, Ravi Pillai, Chandi Ratnatunga, Christodoulos Stefanadis, Keith M Channon
发表日期
2009/5/1
期刊
European heart journal
卷号
30
期号
9
页码范围
1142-1150
出版商
Oxford University Press
简介
Background
Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (eNOS), is considered to be a risk factor for atherosclerosis. However, the mechanisms relating ADMA with vascular function have been evaluated in vitro and in animal models, but its effect in human vasculature is unclear.
Aims
We examined the impact of serum ADMA on endothelial nitric oxide (NO) bioavailability and vascular superoxide radical (O2-) production in patients with advanced atherosclerosis.
Methods and results
Paired samples of saphenous veins (SVs) and internal mammary arteries (IMAs) were collected from 201 patients undergoing coronary bypass surgery, and serum ADMA was measured pre-operatively. The vasomotor responses of SV segments to acetylcholine (ACh) and bradykinin (Bk) were evaluated ex vivo. Vascular …
引用总数
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C Antoniades, C Shirodaria, P Leeson, A Antonopoulos… - European heart journal, 2009