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Purpose

While tumor volume reduction following radiation has been documented in myxoid liposarcomas, it is unclear whether large tumors experience similar volume reduction to smaller tumors.

Materials and Methods

MRI studies performed before and after completion of pre-operative radiation therapy (RT) were examined. Tumor sizes were noted and categorized as large versus small based on size> 10 cm. Tumor volumes were calculated, and operative duration and major wound complications were recorded.

Results

The median largest tumor dimension was 12.4 cm before RT and 8.7 cm after RT. The median tumor volume was 298.9 cm 3 before RT and 106.9 cm 3 after RT. There was no significant difference in the mean percent tumor volume reduction between large tumors and small tumors (p= 0.11, 56.3% vs. 64.5%). Operative duration most strongly correlated to post-RT MRI volume (R 2= 0.674, p< 0.001 …