作者
Marcelo O Dietrich, Jeremy Bober, Jozélia G Ferreira, Luis A Tellez, Yann S Mineur, Diogo O Souza, Xiao-Bing Gao, Marina R Picciotto, Ivan Araújo, Zhong-Wu Liu, Tamas L Horvath
发表日期
2012/8
期刊
Nature neuroscience
卷号
15
期号
8
页码范围
1108-1110
出版商
Nature Publishing Group US
简介
It is not known whether behaviors unrelated to feeding are affected by hypothalamic regulators of hunger. We found that impairment of Agouti-related protein (AgRP) circuitry by either Sirt1 knockdown in AgRP-expressing neurons or early postnatal ablation of these neurons increased exploratory behavior and enhanced responses to cocaine. In AgRP circuit–impaired mice, ventral tegmental dopamine neurons exhibited enhanced spike timing–dependent long-term potentiation, altered amplitude of miniature postsynaptic currents and elevated dopamine in basal forebrain. Thus, AgRP neurons determine the set point of the reward circuitry and associated behaviors.
学术搜索中的文章
MO Dietrich, J Bober, JG Ferreira, LA Tellez, YS Mineur… - Nature neuroscience, 2012