作者
Chris Moran, Thanh G Phan, Jian Chen, Leigh Blizzard, Richard Beare, Alison Venn, Gerald Münch, Amanda G Wood, Josephine Forbes, Timothy M Greenaway, Susan Pearson, Velandai Srikanth
发表日期
2013/12/1
期刊
Diabetes care
卷号
36
期号
12
页码范围
4036-4042
出版商
American Diabetes Association
简介
OBJECTIVE
Type 2 diabetes (T2DM) is associated with brain atrophy and cerebrovascular disease. We aimed to define the regional distribution of brain atrophy in T2DM and to examine whether atrophy or cerebrovascular lesions are feasible links between T2DM and cognitive function.
RESEARCH DESIGN AND METHODS
This cross-sectional study used magnetic resonance imaging (MRI) scans and cognitive tests in 350 participants with T2DM and 363 participants without T2DM. With voxel-based morphometry, we studied the regional distribution of atrophy in T2DM. We measured cerebrovascular lesions (infarcts, microbleeds, and white matter hyperintensity [WMH] volume) and atrophy (gray matter, white matter, and hippocampal volumes) while blinded to T2DM status. With use of multivariable regression, we examined for mediation or effect modification of the association …
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C Moran, TG Phan, J Chen, L Blizzard, R Beare… - Diabetes care, 2013