作者
Jin Di, Shanshan Yao, Yanqi Ye, Zheng Cui, Jicheng Yu, Tushar K Ghosh, Yong Zhu, Zhen Gu
发表日期
2015/9/22
期刊
ACS nano
卷号
9
期号
9
页码范围
9407-9415
出版商
American Chemical Society
简介
Mechanical force-based stimulus provides a simple and easily accessible manner for spatiotemporally controlled drug delivery. Here we describe a wearable, tensile strain-triggered drug delivery device consisting of a stretchable elastomer and microgel depots containing drug loaded nanoparticles. By applying a tensile strain to the elastomer film, the release of drug from the microdepot is promoted due to the enlarged surface area for diffusion and Poisson’s ratio-induced compression on the microdepot. Correspondingly, both sustained drug release by daily body motions and pulsatile release by intentional administration can be conveniently achieved. Our work demonstrated that the tensile strain, applied to the stretchable device, facilitated release of therapeutics from microdepots for anticancer and antibacterial treatments. Moreover, polymeric microneedles were further integrated with the stretch-responsive …
学术搜索中的文章
J Di, S Yao, Y Ye, Z Cui, J Yu, TK Ghosh, Y Zhu, Z Gu - ACS nano, 2015