作者
Mei He, Hiroshi Kubo, Kota Ishizawa, Ahmed E Hegab, Yasuhiko Yamamoto, Hiroshi Yamamoto, Mutsuo Yamaya
发表日期
2007/12
期刊
American Journal of Physiology-Lung Cellular and Molecular Physiology
卷号
293
期号
6
页码范围
L1427-L1436
出版商
American Physiological Society
简介
The pathogenesis of pulmonary fibrosis remains unclear. The receptor for advanced glycation end-products (RAGE) is a multi-ligand receptor known to be involved in the process of fibrotic change in several organs, such as peritoneal fibrosis and kidney fibrosis. The aim of this study was to examine the contribution of RAGE during the acute inflammation and chronic fibrotic phases of lung injury induced by intratracheal instillation of bleomycin in mice. Bleomycin-induced lung fibrosis was evaluated in wild-type and RAGE-deficient (RAGE−/−) mice. Bleomycin administration to wild-type mice caused an initial pneumonitis that evolved into fibrosis. While RAGE−/− mice developed a similar early inflammatory response, the mice were largely protected from the late fibrotic effects of bleomycin. The protection afforded by RAGE deficiency was accompanied by reduced pulmonary levels of the potent RAGE-inducible …
引用总数
学术搜索中的文章
M He, H Kubo, K Ishizawa, AE Hegab, Y Yamamoto… - American Journal of Physiology-Lung Cellular and …, 2007