作者
Qinghua He, Gui Xue, Chuansheng Chen, Zhonglin Lu, Qi Dong, Xuemei Lei, Ni Ding, Jin Li, He Li, Chunhui Chen, Jun Li, Robert K Moyzis, Antoine Bechara
发表日期
2010/11/30
期刊
Neuropharmacology
卷号
59
期号
6
页码范围
518-526
出版商
Pergamon
简介
Risky decision making is a complex process that involves weighing the probabilities of alternative options that can be desirable, undesirable, or neutral. Individuals vary greatly in how they make decisions either under ambiguity and/or under risk. Such individual differences may have genetic bases. Based on previous studies on the genetic basis of decision making, two decision making tasks [i.e., the Iowa Gambling Task (IGT) and Loss Aversion Task (LAT)] were used to test the effect of 5-HTTLPR polymorphism on decision making under ambiguity and under risk in a large Han Chinese sample (572 college students, 312 females). Basic intelligence and memory tests were also included to control for the influence of basic cognitive abilities on decision making. We found that 5-HTTLPR polymorphism significantly influenced performance in both IGT and LAT. After controlling for intelligence and memory abilities …
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