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Nurses have been found to experience high levels of stress which contributes to health challenges and decreases their efficiency. Nurse managers may experience higher levels of stress due to their complex and multi-faceted roles and responsibilities. A quantitative descriptive cross-sectional approach was used to identify how nurse managers experience stress and strategies used to reduce stress. Three hospitals were randomly selected, and 45 nurse managers were also selected using disproportionate stratified sampling technique. Simple random sampling was employed to select 15 nurse managers from each hospital. Structured questionnaire was used for data collection, and the data was analyzed using both inferential and descriptive statistics to describe the sample and determine factors that influence stress. The study revealed that common causes of stress among nurse managers are lack of break period during shifts (95.6%), staff shortage (97.8%), inadequate support from management (93.3%), poor working conditions (91.1%) and inadequate resources (91.1%). The major predictor of stress among nurse managers is the type of unit (F= 9.546, p<. 05, R2=. 205). Headache (78.3%), backache (73.9%) and fatigue (82.6%) are the major physical stress experienced by nurse managers. Frustration (84.8%) is the major emotional stress experienced by nurse managers and the major type of psychological stress experienced by nurse managers is lack of concentration (67.4%). The major coping strategies of stress among nurse managers are expression of feelings instead of bottling them up (91.1%), accepting the things one cannot …