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Rheumatoid arthritis is chronic inflammation disorder that can be treated with anti-inflammatory drug such as methylprednisolone. Several medicinal plants shave the potential to be used in arthritis therapy, one of which is Muntingia calabura L. The objective of this research was to study the antirheumatic activity of M. calabura leaves ethanol extract and its n-hexane, ethyl acetate, and water fractions in a rheumatoid arthritic rat model. Rheumatoid was induced in rats by intraplantar injection of Complete Freund’s Adjuvant (CFA) into the right foot paw of Wistar rats. The paw volume was measured by a plethysmometer. The histology of right foot paw was carried out. For chronic CFA inflammation, induced paw edema assay was used, whereas chronic inflammation was assessed by CFA induced arthritis. The histopathology of synovial joints (paw) was carried out. The results of the study …