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The normal architecture and biologic function of the kidney depends on an integrated network of cellular and extracellular matrix interactions. The extracellular matrix, in addition to its role in the organization of renal tissue, also provides structural dimensions for fluid and protein movement through which physiologic systems operate to modify the filtration of ions and macromolecules, or to alter the size, proliferation and biological expressions of renal cells [1], Thus, the renal extracellular milieu constitutes the primary communication and signal processing pathway for the constituents of surrounding tissue. Although poorly characterized and poorly understood, recent advances in molecular and cellular biology have provided a variety of new experimental approaches from which to further analyze this subject matter [2–5].

Several highly dynamic processes are thought to modulate the integrity of the extracellular matrix …