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To study the effect of melatonin administration on glucose metabolism in humans in the morning and evening.

Placebo-controlled, single-blind design.

Laboratory assessments.

21 healthy women (24 ± 6 y; body mass index: 23.0 ± 3.3 kg/m²).

Glucose tolerance was assessed by oral glucose tolerance tests (OGTT; 75 g glucose) on 4 occasions: in the morning (9 AM), and evening (9 PM); each occurring 15 minutes after melatonin (5 mg) and placebo administration on 4 non-consecutive days.

Melatonin administration impaired glucose tolerance. When administered in the morning, melatonin significantly increased the incremental area under the curve (AUC) and maximum concentration (Cmax) of plasma …