作者
Yiming Pan, Yun Li, Jagadish K Chhetri, Pan Liu, Bowen Li, Zuyun Liu, Guanghou Shui, Lina Ma
发表日期
2024/2/12
期刊
Aging Clinical and Experimental Research
卷号
36
期号
1
页码范围
36
出版商
Springer International Publishing
简介
Background
Intrinsic capacity is the combination of individual physical and mental abilities, reflecting the aging degree of the older adults. However, the mechanisms and metabolic characteristics of the decline in intrinsic capacity are still unclear.
Aims
To identify metabolic signatures and associated pathways of decline in intrinsic capacity based on the metabolite features.
Methods
We recruited 70 participants aged 77.19 ± 8.31 years. The five domains of intrinsic capacity were assessed by Short Physical Performance Battery (for mobility), Montreal cognition assessment (for cognition), 30-Item Geriatric Depression Scale (for psychology), self-reported hearing/visual impairment (for sensory) and Nutritional risk screening (for vitality), respectively. The serum samples of participants were analyzed by liquid chromatography-mass spectrometry-based metabolomics, followed by metabolite set enrichment analysis and …
学术搜索中的文章
Y Pan, Y Li, JK Chhetri, P Liu, B Li, Z Liu, G Shui, L Ma - Aging Clinical and Experimental Research, 2024