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The study has been carried out in Kalakad-Mundanthurai Tiger Reserve of Western Ghats, Tirunelveli, Tamil Nadu. Kanikkar, the predominant tribal community has their settlements in different areas in the Reserve Forest. Fifty medicinal plants belonging to 36 families are identified which have been employed by the tribal community for the treatment of rheumatism. The plants have been enumerated with botanical names followed by family name, local (Kanikkar) name, plant parts used, mode of administration and uses.