作者
Rúben F Pereira, Aureliana Sousa, Cristina C Barrias, Ardeshir Bayat, Pedro L Granja, Paulo J Bártolo
发表日期
2017/12
来源
Biomanufacturing Reviews
卷号
2
页码范围
1-26
出版商
Springer International Publishing
简介
Bioprinting technologies are powerful additive biofabrication techniques to produce cellular constructs for skin tissue engineering owing to their unique ability to precisely pattern living and non-living materials in pre-defined spatial locations. This unique feature, combined with the computer controlled printing and medical imaging techniques, enable researchers and clinicians to generate patient specific constructs partly replicating the intricate compositional and architectural organization of the skin. Bioprinting has been used to automatically dispense hydrogels with skin cells located in prescribed sites that promote skin formation in vitro and in vivo. Current skin bioprinting approaches mostly rely on the sequential printing of fibroblasts and keratinocytes embedded within a homogeneous hydrogel. Although such approaches have already been translated to pre-clinical scenarios, they still present limitations …
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RF Pereira, A Sousa, CC Barrias, A Bayat, PL Granja… - Biomanufacturing Reviews, 2017