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The aim of the present study was to formulate chitosan-coated alginate nanoparticles containing the drug diphenhydramine hydrochloride (DHH).

Diphenhydramine hydrochloride (DHH) is the prototype of H₁-antihistaminic drugs. It is a lipophilic drug, that easily crosses the blood–brain barrier when taken orally causing decrements in alertness and performance. Multiple applications of topical drug products are required. Thus, drug incorporation in nanocarriers would increase the skin penetration powers increasing the drug efficacy.

Chitosan-coated alginate (CCA) nanoparticles were prepared via polyelectrolyte complex technique adopting 2³ full factorial designs. Three factors, namely, alginate concentration, drug-to-alginate ratio and CaCl₂ volume, each in two levels were studied. The prepared formulae were evaluated utilizing entrapment efficiency (EE), particle size (PS …