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Platelet refrigeration decreases the risk of bacterial contamination and may preserve function better than standard-of-care room temperature (RT) storage. Benefits could include lower transfusion-related complications, decreased costs, improved hemostasis in acutely bleeding patients, and extended shelf life. In this study, we compared the effects of 22 C and 4 C storage on the functional and activation status of apheresis platelets. Apheresis platelets (n= 5 per group) were stored for 5 days at 22 C with agitation (RT) versus at 4 C with agitation (4 C+ AG) and without (4 C). Measurements included platelet counts, mean platelet volume, blood gas analytes, aggregation response, thromboelastography, thromboxane B 2 and soluble CD40 ligand release, activation markers, and microparticle formation. Sample pH levels were within acceptable limits for storage products (pH 6.2–7.4 …