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Although regular exercise has important health benefits, women’s physical activity participation remains low. Addressing the gender- and generation-specific barriers in an intervention may help women become more physically active. Fifty women (mean age = 45 years) participated in a six-session cognitive-behavioral intervention. Baseline, post-intervention, and follow-up data were collected. Total physical activity levels increased from baseline to post-intervention and were maintained at long-term follow-up. This research suggests that participation in a comprehensive, cognitive-behavioral, and empowerment-based physical activity intervention, tailored to address women’s distinct constraints and pressures due to sociopsychological experiences, can facilitate increased physical activity among white, middle-aged women.