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PURPOSE: Cystic fibrosis (CF) leads to multi-system morbidity, but progressive respiratory decline from infection and inflammation remains a primary cause of hospitalization and premature death. Therefore, patients with CF are often treated with broad spectrum antimicrobials with minimal regard for maintaining a healthy respiratory microbiome. Recent studies suggest a relationship between having CF with low microbiota diversity and worsened lung function. The significance of certain respiratory colonizers, including Trichosporon, remains unclear, and consequently treatment guidelines are lacking. Our study evaluates risk factors and outcomes related to Trichosporon colonization among patients with CF.

METHODS: Using the Military Healthcare System database, we identified patients with CF who were< 26 years old and followed between 2012 and 2017 across 6 CF centers. All available respiratory culture …