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To develop a noninvasive prognostic imaging biomarker related to hypoxia to predict SABR tumor control.

A total of 145 subcutaneous syngeneic Dunning prostate R3327-AT1 rat tumors were focally irradiated once using cone beam computed tomography guidance on a small animal irradiator at 225 kV. Various doses in the range of 0 to 100 Gy were administered, while rats breathed air or oxygen, and tumor control was assessed up to 200 days. Oxygen-sensitive magnetic resonance imaging (MRI) (T₁-weighted, ΔR₁, ΔR₂*) was applied to 79 of these tumors at 4.7 T to assess response to an oxygen gas breathing challenge on the day before irradiation as a probe of tumor hypoxia.

Increasing radiation dose in the range of 0 to 90 Gy enhanced tumor control of air-breathing rats with a TCD₅₀ estimated at 59.6 ± 1.5 Gy. Control was significantly improved at some doses when …