作者
Allan V Kalueff, David J Echevarria, Sumit Homechaudhuri, Adam Michael Stewart, Adam D Collier, Aleksandra A Kaluyeva, Shaomin Li, Yingcong Liu, Peirong Chen, JiaJia Wang, Lei Yang, Anisa Mitra, Subharthi Pal, Adwitiya Chaudhuri, Anwesha Roy, Missidona Biswas, Dola Roy, Anupam Podder, Manoj K Poudel, Deepshikha P Katare, Ruchi J Mani, Evan J Kyzar, Siddharth Gaikwad, Michael Nguyen, Cai Song
发表日期
2016/1/1
期刊
Aquatic Toxicology
卷号
170
页码范围
297-309
出版商
Elsevier
简介
Zebrafish (Danio rerio) are rapidly emerging as an important model organism for aquatic neuropharmacology and toxicology research. The behavioral/phenotypic complexity of zebrafish allows for thorough dissection of complex human brain disorders and drug-evoked pathological states. As numerous zebrafish models become available with a wide spectrum of behavioral, genetic, and environmental methods to test novel drugs, here we discuss recent zebrafish phenomics methods to facilitate drug discovery, particularly in the field of biological psychiatry. Additionally, behavioral, neurological, and endocrine endpoints are becoming increasingly well-characterized in zebrafish, making them an inexpensive, robust and effective model for toxicology research and pharmacological screening. We also discuss zebrafish behavioral phenotypes, experimental considerations, pharmacological candidates and relevance …
学术搜索中的文章
AV Kalueff, DJ Echevarria, S Homechaudhuri… - Aquatic Toxicology, 2016