作者
Olivier Farges, David Fuks, Emmanuel Boleslawski, Yves-Patrice Le Treut, Denis Castaing, Alexis Laurent, Christian Ducerf, Michel Rivoire, Philippe Bachellier, Laurence Chiche, Gennaro Nuzzo, Jean Marc Regimbeau
发表日期
2011/11/1
期刊
Annals of surgery
卷号
254
期号
5
页码范围
824-830
出版商
LWW
简介
Objective:
Define the optimal surgical margin in patients undergoing surgery for intrahepatic cholangiocarcinoma (IHCC).
Background Data:
Surgery is the most effective treatment for IHCC. However, the influence of R1 resection on outcome is controversial and that of margin width has not been evaluated.
Methods:
We studied 212 patients undergoing curative resection of mass-forming–type IHCC. The respective influences on survival of resection status (R0 vs R1), surgical margin width, pTNM stage, and the latter's components were evaluated.
Results:
Incidence of R1 resection was 24%. Overall, R1 resection was not an independent predictor of survival [odds ratio (OR) 1.2 (0.7–2.1)] in contrast to the pTNM stage [OR 2.10 (1.2–3.5)]. In the 78 pN+ patients, survival was similar after R0 and R1 resections (median: 18 vs 13 months, respectively, P= 0.1). In the 134 pN0 patients, R1 resection was an independent …
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O Farges, D Fuks, E Boleslawski, YP Le Treut… - Annals of surgery, 2011