作者
Emily Beglarian, Elizabeth Costello, Douglas I Walker, Hongxu Wang, Tanya L Alderete, Zhanghua Chen, Damaskini Valvi, Brittney O Baumert, Sarah Rock, Bruna Rubbo, Max T Aung, Frank D Gilliland, Michael I Goran, Dean P Jones, Rob McConnell, Sandrah P Eckel, David V Conti, Jesse A Goodrich, Lida Chatzi
发表日期
2024/3/1
期刊
Environmental Research
卷号
244
页码范围
117611
出版商
Academic Press
简介
Background
Per- and polyfluoroalkyl substances (PFAS) may impair bone development in adolescence, which impacts life-long bone health. No previous studies have examined prospective associations of individual PFAS and their mixture with bone mineral density (BMD) changes in Hispanic young persons, a population at high risk of osteoporosis in adulthood.
Objectives
To examine associations of individual PFAS and PFAS mixtures with longitudinal changes in BMD in an adolescent Hispanic cohort and examine generalizability of findings in a mixed-ethnicity young adult cohort (58.4% Hispanic).
Methods
Overweight/obese adolescents from the Study of Latino Adolescents at Risk of Type 2 Diabetes (SOLAR; n = 304; mean follow-up = 1.4 years) and young adults from the Southern California Children's Health Study (CHS; n = 137; mean follow-up = 4.1 years) were included in this study. Plasma PFAS were …
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E Beglarian, E Costello, DI Walker, H Wang… - Environmental Research, 2024