作者
Mark E Howard, Amanda J Piper, Bronwyn Stevens, Anne E Holland, Brendon J Yee, Eli Dabscheck, Duncan Mortimer, Angela T Burge, Daniel Flunt, Catherine Buchan, Linda Rautela, Nicole Sheers, David Hillman, David J Berlowitz
发表日期
2017/5/1
期刊
Thorax
卷号
72
期号
5
页码范围
437-444
出版商
BMJ Publishing Group Ltd
简介
Background
Obesity hypoventilation syndrome (OHS) is the most common indication for home ventilation, although the optimal therapy remains unclear, particularly for severe disease. We compared Bi-level and continuous positive airways pressure (Bi-level positive airway pressure (PAP); CPAP) for treatment of severe OHS.
Methods
We conducted a multicentre, parallel, double-blind trial for initial treatment of OHS, with participants randomised to nocturnal Bi-level PAP or CPAP for 3 months. The primary outcome was frequency of treatment failure (hospital admission, persistent ventilatory failure or non-adherence); secondary outcomes included health-related quality of life (HRQoL) and sleepiness.
Results
Sixty participants were randomised; 57 completed follow-up and were included in analysis (mean age 53 years, body mass index 55 kg/m2, PaCO2 60 mm Hg). There was no difference in treatment failure …
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ME Howard, AJ Piper, B Stevens, AE Holland, BJ Yee… - Thorax, 2017
