作者
James E Allison, Lori C Sakoda, Theodore R Levin, Jo P Tucker, Irene S Tekawa, Thomas Cuff, Mary Pat Pauly, Lyle Shlager, Albert M Palitz, Wei K Zhao, J Sanford Schwartz, David F Ransohoff, Joseph V Selby
发表日期
2007/10/3
期刊
Journal of the National Cancer Institute
卷号
99
期号
19
页码范围
1462-1470
出版商
Oxford University Press
简介
Background
One type of fecal occult blood test (FOBT), the unrehydrated guaiac fecal occult blood test (GT), is recommended by the United States Preventive Services Task Force and the Institute of Medicine for use in screening programs, but it has relatively low sensitivity as a single test for detecting advanced colonic neoplasms (cancer and adenomatous polyps ≥1 cm in diameter). Thus, improving the sensitivity of FOBT should make colon cancer screening programs that use these tests more effective.
Methods
We assessed prospectively the performance characteristics of two newer FOBTs in 5841 subjects at average risk for colorectal cancer in a large group–model managed care organization. The tests evaluated included a sensitive GT, a fecal immunochemical test (FIT), and the combination of both tests. Patients with positive and negative test results were advised to …
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JE Allison, LC Sakoda, TR Levin, JP Tucker, IS Tekawa… - Journal of the National Cancer Institute, 2007