作者
Marcia Irene F Canto, Sebouh Setrakian, Joseph Willis, Amitabh Chak, Robert Petras, Neil R Powe, Michael V Sivak Jr
发表日期
2000/5/1
期刊
Gastrointestinal endoscopy
卷号
51
期号
5
页码范围
560-568
出版商
Mosby
简介
Background
Endoscopically applied methylene blue selectively stains specialized columnar epithelium in Barrett's esophagus.
Methods
The diagnostic yield and cost of cancer surveillance in patients with Barrett's esophagus using methylene blue–directed biopsies (MBDB) were compared with surveillance using a “jumbo” random biopsy technique in a prospective, sequential, controlled trial. Esophagogastroduodenoscopy was performed with either MBDB or random biopsy in a randomized sequence. The proportions of various types of epithelia in each biopsy were estimated and dysplasia was graded in a blinded fashion.
Results
Forty-three patients with short- (n = 8), limited- (n = 10), and long-segment (n = 25) Barrett's esophagus were studied. Using MBDB technique, the average number of biopsies obtained per patient was significantly lower and the proportion of specialized columnar epithelium in each …
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MIF Canto, S Setrakian, J Willis, A Chak, R Petras… - Gastrointestinal endoscopy, 2000