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Ded1p is an ATP‐dependent RNA helicase that promotes translation and accumulates in stress granules. Ded1 is essential in budding yeast, promotes the translation of a large number of mRNA transcripts, and cooperates with eIF4G and eIF4A to promote translation initiation (Gao et al., 2016; Sen et al., 2015; Berthelot, 2005). We are interested in how Ded1p function is regulated via post‐translational modifications. Ded1p is methylated by Hmt1 at four arginines–three in the N terminus and one in the C terminus (Erce et al., 2013). We generated mutant alleles that alter these four amino acids to alanine (ded1‐quadA) or lysine (ded1‐quadK). Alanine cannot be methylated, is smaller and neutral, while lysine would similarly not be methylated, but has the same charge and similar shape as arginine. These ded1 alleles can complement a ded1 null, indicating that the residues, and their methylation, are not required for …