作者
Natalia O Kuchuk, Natasja M van Schoor, Saskia M Pluijm, Arkadi Chines, Paul Lips
发表日期
2009/4/1
期刊
Journal of bone and mineral research
卷号
24
期号
4
页码范围
693-701
出版商
John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR)
简介
Poor vitamin D status is common in the elderly and is associated with bone loss and fractures. The aim was to assess worldwide vitamin D status in postmenopausal women with osteoporosis according to latitude and economic status, in relation to parathyroid function, bone turnover markers, and BMD. The study was performed in 7441 postmenopausal women from 29 countries participating in a clinical trial on bazedoxifene (selective estrogen receptor modulator), with BMD T‐score at the femoral neck or lumbar spine ≤ −2.5 or one to five mild or moderate vertebral fractures. Serum 25(OH)D, PTH, alkaline phosphatase (ALP), bone turnover markers osteocalcin (OC) and C‐terminal cross‐linked telopeptides of type I collagen (CTX), and BMD of the lumbar spine, total hip, femoral neck, and trochanter were measured. The mean serum 25(OH)D level was 61.2 ± 22.4 nM. The prevalence of 25(OH)D <25, 25–50 …
引用总数
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