作者
Ankur Gulati, Andrew Jabbour, Tevfik F Ismail, Kaushik Guha, Jahanzaib Khwaja, Sadaf Raza, Kishen Morarji, Tristan DH Brown, Nizar A Ismail, Marc R Dweck, Elisa Di Pietro, Michael Roughton, Ricardo Wage, Yousef Daryani, Rory O’Hanlon, Mary N Sheppard, Francisco Alpendurada, Alexander R Lyon, Stuart A Cook, Martin R Cowie, Ravi G Assomull, Dudley J Pennell, Sanjay K Prasad
发表日期
2013/3/6
期刊
Jama
卷号
309
期号
9
页码范围
896-908
出版商
American Medical Association
简介
Importance
Risk stratification of patients with nonischemic dilated cardiomyopathy is primarily based on left ventricular ejection fraction (LVEF). Superior prognostic factors may improve patient selection for implantable cardioverter-defibrillators (ICDs) and other management decisions.
Objective
To determine whether myocardial fibrosis (detected by late gadolinium enhancement cardiovascular magnetic resonance [LGE-CMR] imaging) is an independent and incremental predictor of mortality and sudden cardiac death (SCD) in dilated cardiomyopathy.
Design, Setting, and Patients
Prospective, longitudinal study of 472 patients with dilated cardiomyopathy referred to a UK center for CMR imaging between November 2000 and December 2008 after presence and extent of midwall replacement fibrosis were determined. Patients were followed up through December 2011.
Main Outcome Measures
Primary end point was …
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A Gulati, A Jabbour, TF Ismail, K Guha, J Khwaja… - Jama, 2013