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The local population of the Zerhoun region of Morocco has a rich ancestral tradition in the field of herbal medicine. Indeed, several plants with medicinal properties are at the origin of intoxications thus constituting a rather serious public health problem. Thus, the present work is a contribution to the knowledge of toxic plants; it is a matter of identifying among the medicinal plants used in the region of Zerhoun, those declared toxic by the local population. The survey identified 17 wild plants (15.31%) based on their local vernacular names. A field survey was conducted in a second time for the collection and preliminary identification of samples of these plants, then their taxonomic identification was made based mainly on the Moroccan Flora. The toxic effect plants cataloged belong to 13 families and used mainly internally, with random doses to treat a variety of diseases. This anarchic, non-rational use of medicinal plants presents a risk of intoxication. Awareness and user training and legislation in the field of traditional herbal medicine are needed.