作者
Daphne Holt, Stephanie DeCross, Drew Coman, Ben Shapero, Avram Holmes, Randy Buckner, Maurizio Fava, Amy Farabaugh
发表日期
2019/4/9
期刊
Schizophrenia Bulletin
卷号
45
期号
Supplement_2
页码范围
S90-S91
出版商
Oxford University Press
简介
Background
Prior studies have found evidence for abnormalities of medial temporal lobe structures in patients with psychotic disorders. It has been hypothesized that these abnormalities, which have been linked to dysregulation of dopaminergic neurotransmission in animal models of psychosis, may be associated with a cognitive bias to mislabel neutral events or objects in the environment as salient, which may, in turn, give rise to delusional beliefs and other psychotic symptoms. One persistent challenge for this line of research arises from the confounds associated with testing such models in psychotic disorder patients who have been treated with antipsychotic medication. In light of recent evidence for a neurobiological continuum between clinical and subclinical psychosis, in the current study, medial temporal lobe connectivity was measured in non-help-seeking young people (college students …