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Purslane (Khurfeh) is one of the richest sources of omega3 fatty acids in plants and it has many antioxidants and minerals in its different parts. High density lipoprotein (HDL) has antioxidant effects because of Paraoxanase-1 (PON1) enzyme which attaches to HDL particles and circulates with it in blood. PON1 is responsible for hydrolysis of oxidized phospholipids. The aims of this study were investigating the Purslane effects on Paraoxanase-1 activity and lipoproteins levels, especially oxidized low density lipoprotein (OxLDL) and to compare these effects with Lovastatin. Fasting venous blood samples were obtained from patients who were referred to an internal clinic with LDL-C more than 100 mg/dl. Five ml of blood was taken before and 45 days after taking Purslane or Lovastatin. Subsequently the levels of all variables in the samples were measured using standard methods …