作者
Y Eralp, D Derin, Y Ozluk, Erdem Yavuz, N Guney, P Saip, M Muslumanoglu, A Igci, S Kücücük, M Dincer, A Aydiner, E Topuz
发表日期
2008/4/1
期刊
Annals of oncology
卷号
19
期号
4
页码范围
669-674
出版商
Elsevier
简介
Background
Triple-negative breast cancer is estimated to account for 15%–20% of all patients with breast cancer and is considered as a prognostically unfavorable subset. The aim of this study is to evaluate the prognostic impact of various molecular factors in patients with triple-negative breast cancer.
Patients and methods
Tumor specimens from 109 patients with receptor-negative (estrogen receptor and progesterone receptor) breast cancer were analyzed for mitogen-activated protein kinase (MAPK), epidermal growth factor receptor (EGFR) and phosphoinositol-3-kinase (PI3K) expression by immunohistochemistry. The prognostic significance of these molecular factors, in addition to various prognostic variables, was investigated.
Results
Fifteen (13.8%), 38 (34.9%) and 33 patients (30.3%) had positive staining for EGFR, MAPK and PI3K, respectively. MAPK was associated with anthracycline resistance (P = 0.008 …
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Y Eralp, D Derin, Y Ozluk, E Yavuz, N Guney, P Saip… - Annals of oncology, 2008